Differences of the antiplatelet treatment with acetylsalicylic acid

Do acetylsalicylic acid and other antiplatelet drugs prevent preeclampsia?

Influence of vitamin E on the antiplatelet effect of acetylsalicylic acid in human blood.

We analysed the in vitro interaction between acetylsalicylic acid and vitamin E on the principal antiplatelet sites of action of acetylsalicylic acid, i.e., platelet aggregation, prostanoid production in platelets and leukocytes, and nitric oxide synthesis. Aggregation was measured in whole blood and in platelet-rich plasma (PRP) with ADP, collagen or arachidonic acid as platelet inducers, and ...

Sex-dependent differences in the activities of acetylsalicylic acid-esterases in mouse kidneys.

Acetylsalicylic acid (ASA), the most used drug worldwide, is hydrolyzed to salicylic acid and acetate by esterases present in tissues of several species including humans. Sex differences in drug metabolism by rodent liver are documented in the literature. In this paper we report a difference in the activities of the esterases (ASA-esterase I and II) in the kidneys of male and female mice. In th...

modern surgical techniques in treatment of patients with cleft lip & cleft palate

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The protein binding of acetylsalicylic acid and salicylic acid.

Quantitative experiments to study the binding of acetylsalicylic acid (ASA) and salicylic acid (SA) by human serum albumin (HSA) were carried out using ‘4C-labeled ASA or SA and gel filtration to separate the free from the bound forms. Two binding procedures were employed: the ASA or SA was incubated with the HSA, or the mixture was placed in an equilibrium dialysis cell. By withdrawing samples...